Titel:	Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart
Autor(en):	Santalla, Manuela García, Alejandra Mattiazzi, Alicia Valverde, Carlos A. Schiemann, Ronja Paululat, Achim Hernández, Greco Meyer, Heiko Ferrero, Paola
ORCID des Autors:	https://orcid.org/0000-0002-5582-642X https://orcid.org/0000-0002-3590-9586 https://orcid.org/0000-0003-2262-5557 https://orcid.org/0000-0002-8845-6859 https://orcid.org/0000-0002-5318-4443
Zusammenfassung:	Appropriate cardiac performance depends on a tightly controlled handling of Ca2+ in a broad range of species, from invertebrates to mammals. The role of the Ca2+ ATPase, SERCA, in Ca2+ handling is pivotal, and its activity is regulated, inter alia, by interacting with distinct proteins. Herein, we give evidence that 4E binding protein (4E-BP) is a novel regulator of SERCA activity in Drosophila melanogaster during cardiac function. Flies over-expressing 4E-BP showed improved cardiac performance in young individuals associated with incremented SERCA activity. Moreover, we demonstrate that SERCA interacts with translation initiation factors eIF4E-1, eIF4E-2 and eIF4E-4 in a yeast two-hybrid assay. The specific identification of eIF4E-4 in cardiac tissue leads us to propose that the interaction of elF4E-4 with SERCA may be the basis of the cardiac effects observed in 4E-BP over-expressing flies associated with incremented SERCA activity.
Bibliografische Angaben:	Santalla, M., García, A., Mattiazzi, A., Valverde, C. A., Schiemann, R., Paululat, A., Hernández, G., Meyer, H., Ferrero, P. (2022): Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart. PLOS ONE, 17(5), e0267156.
URL:	https://doi.org/10.48693/298 https://osnadocs.ub.uni-osnabrueck.de/handle/ds-202305028735
Schlagworte:	Drosophila melanogaster; Heart; Hyperexpression techniques; Heart rate; Aging; Cardiovascular physiology; Fluorescence imaging; Protein translation
Erscheinungsdatum:	19-Mai-2022
Lizenzbezeichnung:	Attribution 4.0 International
URL der Lizenz:	http://creativecommons.org/licenses/by/4.0/
Publikationstyp:	Einzelbeitrag in einer wissenschaftlichen Zeitschrift [Article]
Enthalten in den Sammlungen:	FB05 - Hochschulschriften Open-Access-Publikationsfonds

Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons