Titel:	Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population
Autor(en):	Chernyak, Boris V. Lyamzaev, Konstantin G. Mulkidjanian, Armen Y.
ORCID des Autors:	https://orcid.org/0000-0001-9921-8031 https://orcid.org/0000-0001-5844-3064 https://orcid.org/0000-0001-9921-8031
Zusammenfassung:	In humans, over-activation of innate immunity in response to viral or bacterial infections often causes severe illness and death. Furthermore, similar mechanisms related to innate immunity can cause pathogenesis and death in sepsis, massive trauma (including surgery and burns), ischemia/reperfusion, some toxic lesions, and viral infections including COVID-19. Based on the reviewed observations, we suggest that such severe outcomes may be manifestations of a controlled suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than an aberrant hyperstimulation of defense responses. We argue that innate immunity may be involved in the implementation of an altruistic programmed death of an organism aimed at increasing the well-being of the whole community. We discuss possible ways to suppress this atavistic program by interfering with innate immunity and suggest that combating this program should be a major goal of future medicine.
Bibliografische Angaben:	Chernyak B.V., Lyamzaev K.G., Mulkidjanian A.Y.: Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population. International Journal of Molecular Sciences. 2021; 22(24):13480.
URL:	https://doi.org/10.48693/236 https://osnadocs.ub.uni-osnabrueck.de/handle/ds-202301278110
Schlagworte:	pathogen-associated molecular patterns (PAMPs); damage-associated molecular patterns (DAMPs); mitochondrially-targeted antioxidants; inflammation; inflammasome; programmed death; phenoptosis; COVID-19
Erscheinungsdatum:	15-Dez-2021
Lizenzbezeichnung:	Attribution 4.0 International
URL der Lizenz:	http://creativecommons.org/licenses/by/4.0/
Publikationstyp:	Einzelbeitrag in einer wissenschaftlichen Zeitschrift [Article]
Enthalten in den Sammlungen:	FB06 - Hochschulschriften Open-Access-Publikationsfonds

Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons