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Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population

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https://doi.org/10.48693/236
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dc.creatorChernyak, Boris V.-
dc.creatorLyamzaev, Konstantin G.-
dc.creatorMulkidjanian, Armen Y.-
dc.date.accessioned2023-01-27T10:55:15Z-
dc.date.available2023-01-27T10:55:15Z-
dc.date.issued2021-12-15-
dc.identifier.citationChernyak B.V., Lyamzaev K.G., Mulkidjanian A.Y.: Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population. International Journal of Molecular Sciences. 2021; 22(24):13480.ger
dc.identifier.urihttps://doi.org/10.48693/236-
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/ds-202301278110-
dc.description.abstractIn humans, over-activation of innate immunity in response to viral or bacterial infections often causes severe illness and death. Furthermore, similar mechanisms related to innate immunity can cause pathogenesis and death in sepsis, massive trauma (including surgery and burns), ischemia/reperfusion, some toxic lesions, and viral infections including COVID-19. Based on the reviewed observations, we suggest that such severe outcomes may be manifestations of a controlled suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than an aberrant hyperstimulation of defense responses. We argue that innate immunity may be involved in the implementation of an altruistic programmed death of an organism aimed at increasing the well-being of the whole community. We discuss possible ways to suppress this atavistic program by interfering with innate immunity and suggest that combating this program should be a major goal of future medicine.eng
dc.relationhttps://doi.org/10.3390/ijms222413480ger
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectpathogen-associated molecular patterns (PAMPs)eng
dc.subjectdamage-associated molecular patterns (DAMPs)eng
dc.subjectmitochondrially-targeted antioxidantseng
dc.subjectinflammationeng
dc.subjectinflammasomeeng
dc.subjectprogrammed deatheng
dc.subjectphenoptosiseng
dc.subjectCOVID-19eng
dc.subject.ddc570 - Biowissenschaften, Biologieger
dc.subject.ddc530 - Physikger
dc.titleInnate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Populationeng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [Article]ger
orcid.creatorhttps://orcid.org/0000-0001-9921-8031-
orcid.creatorhttps://orcid.org/0000-0001-5844-3064-
orcid.creatorhttps://orcid.org/0000-0001-9921-8031-
dc.identifier.doi10.3390/ijms222413480-
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