NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope

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https://doi.org/10.48693/66
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Titel: NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope
Autor(en): Vittadello, Laura
Klenen, Jan
Koempe, Karsten
Kocsor, Laura
Szaller, Zsuzsanna
Imlau, Mirco
ORCID des Autors: https://orcid.org/0000-0003-2824-2127
https://orcid.org/0000-0001-5654-5737
https://orcid.org/0000-0001-8023-0946
https://orcid.org/0000-0002-5343-5636
https://orcid.org/0000-0003-3284-784X
Zusammenfassung: Near-infrared (NIR) marker-based imaging is of growing importance for deep tissue imaging and is based on a considerable reduction of optical losses at large wavelengths. We aim to extend the range of NIR excitation wavelengths particularly to values beyond 1.6 μm in order to profit from the low loss biological windows NIR-III and NIR-IV. We address this task by studying NIR-excitation to NIR-emission conversion and imaging in the range of 1200 up to 2400 nm at the example of harmonic Mg-doped lithium niobate nanoparticles (i) using a nonlinear diffuse femtosecond-pulse reflectometer and (ii) a Tunable hIGh EneRgy (TIGER) widefield microscope. We successfully demonstrate the existence of appropriate excitation/emission configurations in this spectral region taking harmonic generation into account. Moreover, NIR-imaging using the most striking configurations NIR-III to NIR-I, based on second harmonic generation (SHG), and NIR-IV to NIR-I, based on third harmonic generation (THG), is demonstrated with excitation wavelengths from 1.6–1.8 μm and from 2.1–2.2 μm, respectively. The advantages of the approach and the potential to additionally extend the emission range up to 2400 nm, making use of sum frequency generation (SFG) and difference frequency generation (DFG), are discussed.
Bibliografische Angaben: Vittadello, L.; Klenen, J.; Koempe, K.; Kocsor, L.; Szaller, Z.; Imlau, M.: NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope. Nanomaterials 2021, 11, 3193.
URL: https://doi.org/10.48693/66
https://osnadocs.ub.uni-osnabrueck.de/handle/ds-202202116347
Schlagworte: biological windows; NIR-III; NIR-IV; NIR imaging; nonlinear microscopy; nonlinear photonics; deep tissue imaging harmonic nanoparticles; second harmonic generation
Erscheinungsdatum: 25-Nov-2021
Lizenzbezeichnung: Attribution 4.0 International
URL der Lizenz: http://creativecommons.org/licenses/by/4.0/
Publikationstyp: Einzelbeitrag in einer wissenschaftlichen Zeitschrift [article]
Enthalten in den Sammlungen:FB04 - Hochschulschriften
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