NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope

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https://doi.org/10.48693/66
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dc.creatorVittadello, Laura-
dc.creatorKlenen, Jan-
dc.creatorKoempe, Karsten-
dc.creatorKocsor, Laura-
dc.creatorSzaller, Zsuzsanna-
dc.creatorImlau, Mirco-
dc.date.accessioned2022-02-11T09:24:40Z-
dc.date.available2022-02-11T09:24:40Z-
dc.date.issued2021-11-25-
dc.identifier.citationVittadello, L.; Klenen, J.; Koempe, K.; Kocsor, L.; Szaller, Z.; Imlau, M.: NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope. Nanomaterials 2021, 11, 3193.ger
dc.identifier.urihttps://doi.org/10.48693/66-
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/ds-202202116347-
dc.description.abstractNear-infrared (NIR) marker-based imaging is of growing importance for deep tissue imaging and is based on a considerable reduction of optical losses at large wavelengths. We aim to extend the range of NIR excitation wavelengths particularly to values beyond 1.6 μm in order to profit from the low loss biological windows NIR-III and NIR-IV. We address this task by studying NIR-excitation to NIR-emission conversion and imaging in the range of 1200 up to 2400 nm at the example of harmonic Mg-doped lithium niobate nanoparticles (i) using a nonlinear diffuse femtosecond-pulse reflectometer and (ii) a Tunable hIGh EneRgy (TIGER) widefield microscope. We successfully demonstrate the existence of appropriate excitation/emission configurations in this spectral region taking harmonic generation into account. Moreover, NIR-imaging using the most striking configurations NIR-III to NIR-I, based on second harmonic generation (SHG), and NIR-IV to NIR-I, based on third harmonic generation (THG), is demonstrated with excitation wavelengths from 1.6–1.8 μm and from 2.1–2.2 μm, respectively. The advantages of the approach and the potential to additionally extend the emission range up to 2400 nm, making use of sum frequency generation (SFG) and difference frequency generation (DFG), are discussed.eng
dc.relationhttps://doi.org/10.3390/nano11123193ger
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbiological windowseng
dc.subjectNIR-IIIeng
dc.subjectNIR-IVeng
dc.subjectNIR imagingeng
dc.subjectnonlinear microscopyeng
dc.subjectnonlinear photonicseng
dc.subjectdeep tissue imaging harmonic nanoparticleseng
dc.subjectsecond harmonic generationeng
dc.subject.ddc530 - Physikger
dc.titleNIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscopeeng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]ger
orcid.creatorhttps://orcid.org/0000-0003-2824-2127-
orcid.creatorhttps://orcid.org/0000-0001-5654-5737-
orcid.creatorhttps://orcid.org/0000-0001-8023-0946-
orcid.creatorhttps://orcid.org/0000-0002-5343-5636-
orcid.creatorhttps://orcid.org/0000-0003-3284-784X-
dc.identifier.doi10.3390/nano11123193-
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