MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors
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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202105144644
https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202105144644
Titel: | MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors |
Autor(en): | Melnik, Bodo John, Swen Malte Carrera-Bastos, Pedro Schmitz, Gerd |
ORCID des Autors: | https://orcid.org/0000-0002-4501-1809 https://orcid.org/0000-0002-1325-1007 https://orcid.org/0000-0001-5406-9458 https://orcid.org/0000-0002-4218-1300 |
Zusammenfassung: | DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chronic ultraviolet (UV) irradiation cannot exclusively explain the excessive increase of malignant melanoma (MM) incidence since the 1950s. Malignant conversion of a melanocyte to an MM cell and metastatic MM is associated with a steady increase in microRNA-21 (miR-21). At the epigenetic level, miR-21 inhibits key tumor suppressors of the RAS-BRAF signaling pathway enhancing proliferation and MM progression. Increased MM cell levels of miR-21 either result from endogenous upregulation of melanocytic miR-21 expression or by uptake of miR-21-enriched exogenous exosomes. Based on epidemiological data and translational evidence, this review provides deeper insights into environmentally and metabolically induced exosomal miR-21 trafficking beyond UV-irradiation in melanomagenesis and MM progression. Sources of miR-21-enriched exosomes include UV-irradiated keratinocytes, adipocyte-derived exosomes in obesity, airway epithelium-derived exosomes generated by smoking and pollution, diet-related exosomes and inflammation-induced exosomes, which may synergistically increase the exosomal miR-21 burden of the melanocyte, the transformed MM cell and its tumor environment. Several therapeutic agents that suppress MM cell growth and proliferation attenuate miR-21 expression. These include miR-21 antagonists, metformin, kinase inhibitors, beta-blockers, vitamin D, and plant-derived bioactive compounds, which may represent new options for the prevention and treatment of MM. |
Bibliografische Angaben: | Melnik, B.C.; John, S.M.; Carrera-Bastos, P.; Schmitz, G. MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors. Cancers 2020, 12, 2111. |
URL: | https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202105144644 |
Schlagworte: | environment; epigenetics; exosome; melanoma; metabolic syndrome; microRNA-21; prevention; obesity; radiation; therapy |
Erscheinungsdatum: | 29-Jul-2020 |
Lizenzbezeichnung: | Attribution 4.0 International |
URL der Lizenz: | http://creativecommons.org/licenses/by/4.0/ |
Publikationstyp: | Einzelbeitrag in einer wissenschaftlichen Zeitschrift [article] |
Enthalten in den Sammlungen: | FB08 - Hochschulschriften Open-Access-Publikationsfonds |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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cancers_Melnik_etal_2020.pdf | 2,4 MB | Adobe PDF | cancers_Melnik_etal_2020.pdf Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons