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Social Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Mice

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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202003252690
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dc.creatorAmbrée, Oliver-
dc.creatorRuland, Christina-
dc.creatorZwanzger, Peter-
dc.creatorKlotz, Luisa-
dc.creatorBaune, Bernhard T-
dc.creatorArolt, Volker-
dc.creatorScheu, Stefanie-
dc.creatorAlferink, Judith-
dc.date.accessioned2020-03-25T10:43:34Z-
dc.date.available2020-03-25T10:43:34Z-
dc.date.issued2019-07-17-
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: MDPI 2019, 20, 3512ger
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202003252690-
dc.description.abstractAltered adaptive immunity involving T lymphocytes has been found in depressed patients and in stress-induced depression-like behavior in animal models. Peripheral T cells play important roles in homeostasis and function of the central nervous system and thus modulate behavior. However, the T cell phenotype and function associated with susceptibility and resilience to depression remain largely unknown. Here, we characterized splenic T cells in susceptible and resilient mice after 10 days of social defeat stress (SDS). We found equally decreased T cell frequencies and comparably altered expression levels of genes associated with T helper (Th) cell function in resilient and susceptible mice. Interleukin (IL)-17 producing CD4+ and CD8+ T cell numbers in the spleen were significantly increased in susceptible mice. These animals further exhibited significantly reduced numbers of regulatory T cells (Treg) and decreased gene expression levels of TGF-β. Mice with enhanced Th17 differentiation induced by conditional deletion of PPARγ in CD4+ cells (CD4-PPARγKO), an inhibitor of Th17 development, were equally susceptible to SDS when compared to CD4-PPARγWT controls. These data indicate that enhanced Th17 differentiation alone does not alter stress vulnerability. Thus, SDS promotes Th17 cell and suppresses Treg cell differentiation predominantly in susceptible mice with yet unknown effects in immune responses after stress exposure.eng
dc.relationhttps://www.mdpi.com/1422-0067/20/14/3512ger
dc.rightsAttribution 3.0 Germany*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/*
dc.subjectsocial defeateng
dc.subjectimmune responseeng
dc.subjectT cellseng
dc.subjectsusceptibilityeng
dc.subjectresilienceeng
dc.subjectmajor depressioneng
dc.subjectTreg cellseng
dc.subjectTh17 cellseng
dc.subjectbehavioreng
dc.subjectPPARγeng
dc.subject.ddc610 - Medizin, Gesundheitger
dc.subject.ddc570 - Biowissenschaften, Biologieger
dc.titleSocial Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Miceeng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]ger
dc.identifier.doi10.3390/ijms20143512-
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