Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress

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Titel: Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress
Autor(en): Ambrée, Oliver
Ruland, Christina
Scheu, Stefanie
Arolt, Volker
Alferink, Judith
Zusammenfassung: Dysregulation of innate immune responses has frequently been reported in stressassociated psychiatric disorders such as major depression. In mice, enhanced circulating cytokine levels as well as altered innate immune cell numbers have been found after stress exposure. In addition, stress-induced recruitment of peripheral monocytes to the brain has been shown to promote anxiety-like behavior. However, it is yet unclear whether specific differences in the innate immune system are associated with stress susceptibility or resilience in mice. Utilizing chronic social defeat, a model of depression and stress vulnerability, we characterized peripheral and brain-invading myeloid cells in stress-susceptible and resilient animals. In all defeated animals, we found reduced percentages of CD11cC dendritic cells (DCs) by flow cytometry in the spleen when compared to non-defeated controls. Exclusively in susceptible mice conventional DCs of the spleen showed up-regulated expression of MHC class II and co-stimulatory CD80 molecules pointing toward an enhanced maturation phenotype of these cells. Susceptible, but not resilient animals further exhibited an increase in inflammatory Ly6Chi monocytes and higher numbers of spleen-derived CD11bC cells that produced the proinflammatory cytokine tumor necrosis factor (TNF) upon lipopolysaccharide (LPS) stimulation. Increased percentages of peripheral CD45hi CD11bC cells immigrated into the brain of defeated mice, regardless of resilience or susceptibility. However, cellular infiltrates in the brain of susceptible mice contained higher percentages of CC chemokine receptor 2 (CCR2C) Ly6Chi monocytes representing an inflammatory phenotype. Thus, we defined specific stress-related immune signatures involving conventional DCs and inflammatory Ly6Chi monocytes in susceptible and resilient mice. Together, our findings suggest an impact of the innate immune system in vulnerability to stress-related disorders such as major depression.
Bibliografische Angaben: Frontiers in Behavioral Neuroscience Vol. 12, Article 141, Frontiers Media, 2018, S. 1-12, doi: 10.3389/fnbeh.2018.00141
Schlagworte: chronic stress; social defeat; susceptibility; resilience; myeloid cells; major depressive disorder (MDD); monocytes; dendritic cells
Erscheinungsdatum: 13-Jul-2018
Lizenzbezeichnung: Attribution 4.0 International
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Publikationstyp: Einzelbeitrag in einer wissenschaftlichen Zeitschrift [article]
Enthalten in den Sammlungen:FB05 - Hochschulschriften

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