Commentary: Distinct Domains in The Matricellular Protein, Lonely Heart, Are Crucial for Cardiac Extracellular Matrix Formation and Heart Function in Drosophila

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Title: Commentary: Distinct Domains in The Matricellular Protein, Lonely Heart, Are Crucial for Cardiac Extracellular Matrix Formation and Heart Function in Drosophila
Authors: Post, Yanina
Paululat, Achim
Abstract: It is well known that cardiovascular diseases are becoming the number one cause of mortality in developed countries1. Minimal differences in a wide range of biological pathways can lead to organ malfunction or failure. In addition to the heart itself, its surroundings are also crucial for proper organ integrity and functionality. Changes in extracellular matrix (ECM) composition, such as a higher amount of incorporated collagens, can result in cardiac hypertrophy2 or hypertension-related diastolic dysfunction3 by stiffening the surrounding matrix and constricting the embedded organ. Similar observations have been made while studying the heart of the fruit fly, Drosophila melanogaster. In this model organism, altered amounts of ECM components, including Laminin or Collagen IV (Viking), cause impaired cardiac function4. This demonstrates the notable relevance of an organ-specific ECM composition that provides the correct balance of stiffness and elasticity, both in vertebrates and invertebrates. In our recent study we were able to unravel the function of several protein domains belonging to the ADAMTS-like protein Lonely heart5. Furthermore, we analysed its interaction with the Collagen IV-like protein Pericardin and described new interactions within the extracellular matrix that led to a more detailed model of the whole network. In addition, we investigated the impact of altered Pericardin levels on physiological aspects, including locomotion and heart beating parameters, and strengthened the hypothesis that ECM composition is crucial for proper organ functionality. Here we summarize our approaches and comment on additional observations, possible follow-up analyses and restrictions as well as advantages. Moreover, we discuss possible additional roles of ADAMTS-like proteins within an extracellular matrix.
Citations: Journal of Cardiology and Cardiovascular Sciences. Sciaccess Publishers, 2018; 2 (5), S. 1-5
Subject Keywords: ADAMTS proteins; Drosophila heart model; Extracellular matrix; Collagen; Lonely heart; Pericardin
Issue Date: 18-Sep-2018
License name: Attribution 4.0 International
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Type of publication: Einzelbeitrag in einer wissenschaftlichen Zeitschrift [article]
Appears in Collections:FB05 - Hochschulschriften

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