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Biotransformation of fusidic acid and its related derivatives by Streptomyces lividans

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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2005033013
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DC ElementWertSprache
dc.creatorBiukovic, Goran
dc.date.accessioned2010-01-30T14:40:52Z
dc.date.available2010-01-30T14:40:52Z
dc.date.issued2005-03-30T17:17:30Z
dc.date.submitted2005-03-30T17:17:30Z
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2005033013-
dc.description.abstractAs shown in previous studies Streptomyces lividans enzymatically inactivates fusidic acid by specific esterase FusH giving rise to the 16ß-OH derivative, which sponaneously converts to the lactone.in this work it was shown that S. lividans further modifies fusidic acid and both derivatives, which resulted in several new related substances. The two intermediates (La, Lb) were isolated from the culture filtrate of S. lividans, which was grown in the presence of fusidic acid. The differences in their chemical structures indicate the involvement of multiple enzyme reactions related to hydroxylation, hydration, dehydrogenation and isomerization. Several enzymes were identified and two of them (FusG, FusB) were partially characterized. According to their characteristics and the structures of isolated intermediates, the identified enzymes which are involved in biotranformation are conceivably related to the ones implicated in ß oxidation. The biotransformation of fusidic acid and its derivatives by S. lividans is so far unique, since characterized substances La and Lb have not been found in either fusidic acid-producing or fusidic acid-resistant microorganisms.eng
dc.language.isoeng
dc.subjectFusidic acid
dc.subjectStreptomyces
dc.subjectbiotransformation
dc.subjectantibiotics
dc.subject.ddc610 - Medizin, Gesundheitger
dc.titleBiotransformation of fusidic acid and its related derivatives by Streptomyces lividanseng
dc.typeDissertation oder Habilitation [doctoralThesis]-
thesis.locationOsnabrück-
thesis.institutionUniversität-
thesis.typeDissertation [thesis.doctoral]-
thesis.date2004-04-08T12:00:00Z-
elib.elibid323-
elib.marc.edtfangmeier-
elib.dct.accessRightsa-
elib.dct.created2004-06-08T21:04:14Z-
elib.dct.modified2005-03-30T17:17:30Z-
dc.contributor.refereeProf.Dr. Hildgund Schrempf
dc.contributor.refereeProf. Dr. Renate Scheibe
dc.subject.bk35.70 - Biochemie: Allgemeinesger
dc.subject.bk42.20 - Genetikger
dc.subject.bk42.30 - Mikrobiologieger
dc.subject.dnb32 - Biologieger
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